Comparative Study of Antihypertensive Drugs Amlodipine Besylate /Metoprolol Succinate and Nebivolol Hydrochloride /Valsartan Combinations in Bilayer Tablets
نویسندگان
چکیده
منابع مشابه
Simultaneous estimation of amlodipine besylate and nebivolol hydrochloride in pharmaceutical tablets formulation by RP-HPLC using PDA detector
Background: The present work was undertaken with the aim to develop and validate a rapid and consistent RP-HPLC method in which the peaks will be appear with short period of time as per ICH Guidelines. Materials and Methods: The separation was achieved on a a stainless steel analytical column, Eclipse XDB plus C18 column (4.6 X 150 mm; 5 μm) in an isocratic mode. The mobile phase w...
متن کاملDevelopment and Validation of HPTLC Method for Simultaneous Determination of Amlodipine Besylate and Metoprolol Succinate in Bulk and Tablets
A simple, selective, precise high-performance thin-layer chromatographic method for simultaneous determination of amlodipine besylate and metoprolol succinate in bulk and pharmaceutical combined dosage form was developed and validated. The method employed HPTLC aluminum plates precoated with silica gel 60F-254 (10×10) as the stationary phase. The solvent system consisted of toluene:ethyl acetat...
متن کاملSimultaneous estimation of amlodipine besylate and nebivolol hydrochloride in combined dosage form by RP-HPLC
A simple, selective, rapid, precise and economical reverse phase HPLC method has been developed for the simultaneous estimation of Amlodipine Besylate and Nebivolol hydrochloride in pharmaceutical dosage forms. The method was carried out on a Luna C-18, 5 μ column with a mobile phase consisting of 0.005M ammonium acetate solution, acetonitrile and triethylamine in the ratio 60:40:0.1 (v/v) and ...
متن کاملSimultaneous Estimation of Nebivolol Hydrochloride and S- Amlodipine Besylate by High Performance Thin Layer Chromatography
A simple, rapid, and reliable HPTLC method has been established for simultaneous determination of Nebivolol and S-Amlodipine in pharmaceutical dosage forms. Identification and quantification were performed on silica gel 60 F254 HPTLC plates, prewashed with methanol, with chloroform:toluene:methanol:glacialacetic acid, (5:2:3:0.1, v/v/v/v), as mobile phase. This system furnished compact bands fo...
متن کاملDesign, Development and Evaluation of Metoprolol Succinate and Hydrochlorothiazide Bilayer Tablets
Lowering elevated blood pressure (BP) with drug therapy reduces the risk for catastrophic fatal and nonfatal cardiovascular events. Due to the marked variability in an individual patient’s BP response and low response rates with monotherapy, expert groups such as Joint National Committee (JNC) emphasize the value of combination antihypertensive regimen, usually of different classes, having addi...
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ژورنال
عنوان ژورنال: Journal of Drug Delivery and Therapeutics
سال: 2019
ISSN: 2250-1177
DOI: 10.22270/jddt.v9i4-s.3214